Table of Contents

2017 Month : April Volume : 6 Issue : 3 Page : 1-5

COMPARISON STUDY OF DEXMEDETOMIDINE WITH CLONIDINE FOR ATTENUATION OF THE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION.

Gopal Reddy Narra1, Kahalekar Govind2, T. Hareesh3, Chandra Shekhar Reddy4

Corresponding Author:
Dr. Gopal Reddy Narra,
Flat No. 54,
Old V. T. Colony,
Nalgonda-508001,
Telangana State, India.
E-mail: drgopalreddynarra@yahoo.com

ABSTRACT

BACKGROUND

Dexmedetomidine is an 2 adrenoreceptor agonist with sedative, analgesic and anxiolytic properties. It has been investigated recently for its potential safety in neuro, cardio and reno-protection.

The purpose of this study is to compare Dexmedetomidine (Dexomid) with Clonidine for the attenuation of the pressor response to laryngoscopy and intubation.

MATERIALS AND METHODS

This prospective study was done on 60 adult patients. The patients in Group D were given dexomid 1 µg/kg diluted in 10 mL of distilled water IV over 10 minutes beginning 15 mins before the laryngoscopy and in Group C were given IV clonidine 1 µg/kg 5 minutes before the laryngoscopy.

RESULTS

The results of the present study prove that the use of dexomid as a premedication is more useful for the patients who undergo laryngoscopy and intubation when compared to clonidine. Raise of vitals from baseline to 1 minute after intubation were less; heart rate 14.67%, systolic BP 7.23% in the dexomid group when compared to the clonidine groups heart rate and systolic BP 17.26%, 12.68% respectively.

CONCLUSION

Dexmedetomidine is a very useful drug for pre-medication before the laryngoscopy and intubation, which significantly reduced the sympathetic pressor response. Its effect was higher than that of clonidine. But care has to be taken while giving the drug.

KEYWORDS

Dexmedetomidine, Clonidine, Intubation, Sympathetic Stimulation, Pressor Response.

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